Preparation and Evaluation of Solid Dispersions of Ibuprofen Using Glucosamine HCl as a Carrier
Abdul Wahab
Drug Delivery Research Group, Faculty of Pharmacy, Gomal University, D. I. Khan, KPK, Pakistan and Department of Pharmacy, Kohat University of Science and Technology, Kohat, KPK, Pakistan
Amjad Khan
Department of Biotechnology, Quaid-e-Azam University, Islamabad, Pakistan.
Gul Majid Khan *
Drug Delivery Research Group, Faculty of Pharmacy, Gomal University, D. I. Khan, KPK, Pakistan and Department of Pharmacy, Quaid-e-Azam University, Islamabad, Pakistan.
*Author to whom correspondence should be addressed.
Abstract
Aims: The aim of this study was to enhance the solubility and dissolution rate of sparingly soluble drug ibuprofen using glucosamine HCL as a carrier by solid dispersion technique.
Methodology: As Ibuprofen is sparingly water-soluble drug and has low bioavailability, so to enhance its solubility and improve bioavailability solid dispersions with different drug to carrier ratios (1:1, 1:2 and 1:3) were prepared, as solid dispersion is the most effective method for enhancing the solubility and improving the bioavailability of poorly or sparingly water- soluble drugs. In this study Glucosamine HCl was used as a potential hydrophilic carrier to improve the solubility, dissolution rate and bioavailability of poorly water-soluble drug, Ibuprofen from physical mixtures and solid dispersions. Solid dispersions with different drug to carrier ratios were prepared, using solvent evaporation method. Physical mixtures of Ibuprofen and Glucosamine HCl were also prepared for comparison.
Results: All solid dispersions of Ibuprofen and Glucosamine showed considerably higher dissolution rate than corresponding physical mixtures and pure Ibuprofen. Different techniques such DSC, FT-IR, XRD and SEM were used to study the properties of pure Ibuprofen, solid dispersions and physical mixtures. These results confirmed that Glucosamine HCl can increase the solubility and dissolution rate of poorly water-soluble drug, Ibuprofen.
Conclusion: The study shows that the dissolution rate and solubility of sparingly soluble drug Ibuprofen can be improved and enhanced to great extent by solid dispersion technique, using Glucosamine HCl as a carreir. The current study also showed that amino sugar could be used as new carrier for solid dispersion formulations of non-steroidal anti-inflammatory drugs.
Keywords: Solid dispersions, ibuprofen, glucosamine hcl, solvent evaporation, solubility, dissolution rate.