Potential Antioxidant and Anti-Proliferative Activities of Biologically Active Marine Algae Extracts
Taha A. Kumosani
Department of Biochemistry, Faculty of Science, King Abdulaziz University (KAU), Jeddah, Saudi Arabia and Experimental Biochemistry Unit, King Fahd Medical Research Center, King Abdulaziz University (KAU), Saudi Arabia and Production of Natural Products for Industerial health Resaerch Group, King Abdulaziz University (KAU), Saudi Arabia.
Khadijah Saeed Balamash
Department of Biochemistry, Faculty of Science, King Abdulaziz University (KAU), Jeddah, Saudi Arabia.
Hanaa Ghashlan
Department of Biochemistry, Faculty of Science, King Abdulaziz University (KAU), Jeddah, Saudi Arabia.
Youssri Ahmed Mohamed
Department of Biochemistry, Faculty of Science, King Abdulaziz University (KAU), Jeddah, Saudi Arabia and Experimental Biochemistry Unit, King Fahd Medical Research Center, King Abdulaziz University (KAU), Saudi Arabia and Production of Natural Products for Industerial health Resaerch Group, King Abdulaziz University (KAU), Saudi Arabia and Collage of Pharmacy, Ibin Sina Medical Collage, Jeddah, Saudi Arabia.
Othman A. S. Baothman
Department of Biochemistry, Faculty of Science, King Abdulaziz University (KAU), Jeddah, Saudi Arabia.
Mustafa Zeyadi
Department of Biochemistry, Faculty of Science, King Abdulaziz University (KAU), Jeddah, Saudi Arabia.
Soonham Sami Yaghmoor
Experimental Biochemistry Unit, King Fahd Medical Research Center, King Abdulaziz University (KAU), Saudi Arabia and Production of Natural Products for Industerial health Resaerch Group, King Abdulaziz University (KAU), Saudi Arabia.
Areej H. Alyahiby
Experimental Biochemistry Unit, King Fahd Medical Research Center, King Abdulaziz University (KAU), Saudi Arabia.
Rana R. AL-Rasheed
Experimental Biochemistry Unit, King Fahd Medical Research Center, King Abdulaziz University (KAU), Saudi Arabia.
Wafa Y. Alturkistani
Experimental Biochemistry Unit, King Fahd Medical Research Center, King Abdulaziz University (KAU), Saudi Arabia.
Tahani M. Alghamdi
Collage of Pharmacy, Ibin Sina Medical Collage, Jeddah, Saudi Arabia.
Maryam H. AL-Zahrani
Department of Biochemistry, Faculty of Science, King Abdulaziz University (KAU), Jeddah, Saudi Arabia.
Said Salama Moselhy *
Department of Biochemistry, Faculty of Science, King Abdulaziz University (KAU), Jeddah, Saudi Arabia and Experimental Biochemistry Unit, King Fahd Medical Research Center, King Abdulaziz University (KAU), Saudi Arabia and Department of Microbial Biotechnology, Genetic Engineering and Biotechnology Research Division, National Research Center, Dokki, Cairo, Egypt and Bioactive Natural Products Research Group, King Abdulaziz University (KAU), Saudi Arabia and Department of Biochemistry, Faculty of Science, Ain Shams University, Cairo, Egypt.
*Author to whom correspondence should be addressed.
Abstract
Background: Marine microorganisms such as algae were identified a rich sources of biologically active compounds. This study was designed to explore the in vitro antioxidant, anti-apoptotic and anti proliferative activities of different algae [Gracilaria dendroides (GD), Dictyota ciliolata (DC) and Cladophora socialis (CS)] extracts obtained from Red sea at Jeddah.
Materials and Methods: Algae extracts (ethanol, chloroform and water) were tested for antioxidant activity for free radical scavenging and secondly as anti-apoptotic and anti-proliferative activity against different cell lines. Antioxidant capacity was detected by evaluation superoxide anion radicals, reducing potential and assay of phenolic and flavonoid content in extracts.
Results: Chloroform extract of DC (CEDC) was found to have a better free radical scavenging activity (IC50= 310.58 g/ml) than methanol extract (MEDC). MEDC (IC50= 522 g/ml). The phenol level in CEDC and MEDC were 50.1 and 38.18 mg, while flavonoids were 65.58and 41.74 /mg.EDC and EDC were showed ant proliferative against MC7 and HALA 1.
Conclusion: The solvents extracts exhibited promising biological activity as antioxidants and ant proliferative action.
Keywords: Algae extract, antioxidant, antiproliferative