Development and Evaluation of α-Arbutin Based Periorbital Depigmentation Hydrogel Patches for Cosmetic Application
Shantaveer Irappanavar
Department of Pharmacognosy, BVVS Hanagal Shri Kumareshwar College of Pharmacy, Bagalkot-587101, Karnataka, India.
Sushmita Mudalagi
Department of Pharmaceutics, BVVS Hanagal Shri Kumareshwar College of Pharmacy, Bagalkot-587101, Karnataka, India.
Basanagouda Meti
Research scholar Department of Pharmaceutics, BVVS Hanagal Shri Kumareshwar College of Pharmacy, Bagalkot-587101, Karnataka, India.
D Bhumika
Research scholar Department of Pharmaceutics, BVVS Hanagal Shri Kumareshwar College of Pharmacy, Bagalkot-587101, Karnataka, India.
Dadapeer Kapali
Research scholar Department of Pharmaceutics, BVVS Hanagal Shri Kumareshwar College of Pharmacy, Bagalkot-587101, Karnataka, India.
Kavya Yalaburgi
Research scholar Department of Pharmaceutics, BVVS Hanagal Shri Kumareshwar College of Pharmacy, Bagalkot-587101, Karnataka, India.
Sona Masuti
Research scholar Department of Pharmaceutics, BVVS Hanagal Shri Kumareshwar College of Pharmacy, Bagalkot-587101, Karnataka, India.
Laxman S. Vijapur
*
Department of Pharmaceutics, BVVS Hanagal Shri Kumareshwar College of Pharmacy, Bagalkot-587101, Karnataka, India.
*Author to whom correspondence should be addressed.
Abstract
Aim: The present study aims to formulate and evaluate α-arbutin–based hydrogel patches for periorbital depigmentation and management of under-eye dark circles.
Place and Duration of Study: HSK college of pharmacy, Bagalkote.
Methodology: Hydrogel patches were prepared using Agar/PVA (F1), Gelatine/PVA (F2), and Pectin (F3) by solvent-casting method. Formulations were evaluated for organoleptic properties, pH, weight, thickness, swelling index, folding endurance, tensile strength, drug content, FTIR compatibility, antioxidant activity, and in-vitro drug release using Franz diffusion cell.
Results: FTIR confirmed absence of drug–polymer interaction. F1 showed optimal mechanical properties (tensile strength 2.97 kg; folding endurance 321) and swelling (72.97%). Drug content ranged from 85.10 – 89.12%. F2 exhibited highest drug release (95.72% at 90 min), while F1 showed release (75.49%). Antioxidant activity (DPPH) demonstrated strong scavenging potential.
Conclusion: α-Arbutin hydrogel patches were successfully developed with safe pH, good flexibility, enhanced antioxidant activity, and controlled depigmenting agent release. F1 was identified as the most suitable formulation for cosmetic under-eye application.
Keywords: α-Arbutin, hydrogel patches, periorbital hyperpigmentation, dark circles, ascorbic acid