Challenges, Approaches & Applications of Orotransmucosal Drug Delivery System
Hasan Mahmud
Department of Pharmacy, University of Asia Pacific, Dhaka, Bangladesh.
Afnan Sayeid Himi
*
Department of Pharmacy, University of Asia Pacific, Dhaka, Bangladesh.
Md. Sohel Rana
Department of Pharmacy, Jahangirnagar University, Dhaka, Bangladesh.
Kamrunnahar
Department of Pharmacy, State University of Bangladesh, Dhaka, Bangladesh.
Md. Muhtamim Hussain Rifat
Department of Pharmacy, University of Asia Pacific, Dhaka, Bangladesh.
Swarnali Islam
Department of Pharmacy, University of Asia Pacific, Dhaka, Bangladesh.
*Author to whom correspondence should be addressed.
Abstract
Orotransmucosal drug delivery is an alternative method used for a systemic drug delivery system. It is used as a favored route for non-parenteral administration of emergency drugs and agents. It can be used both for lipid-soluble and water-soluble drugs. It increases drug solubility and reduces in permeability of the lipid bilayer membrane. Mucosal surfaces are often rich in blood supply, allowing for rapid drug transport into the systemic circulation and in most cases avoiding degradation by first-pass hepatic metabolism. These systems contact with absorbent surfaces improves absorption at the application site and increases dwell time. It involves several physiological features of the oral cavity. Technical difficulties and biological impediments can be used as broad categories to group oral administration issues. Orotransmucosal drug delivery system uses an absorption rate four times that of the skin. It is easily accessible and heals rapidly from trauma and injury. It has a smaller surface area than the skin and can only be exposed for brief periods of time. Thus, this delivery method is the best for medications with high therapeutic potency. Efficient orotransmucosal drug delivery can be achieved in the oral cavity's buccal, sublingual, palatal and gingival regions. Mastication or chewing food can improve or impair medication absorption in the oral cavity. Mucoadhesive drug delivery systems can be lost or damaged when used to fill chewing gum with drugs that are released when the chewing gum is chewed. This report also provides input for future orotransmucosal drug developments to treat oral mucosa diseases.
Keywords: Orotransmucosal, transmucosal, mucosal, oral mucosa, mucosae, mucoadhesion, mucoadhesive, OTFC