A Comparative Pharmaceutico-Analytical Study of Saindavadhi Ghrita Prepared with Murchchhit and Amurchchhit Ghrita and Evaluation of Its Antiepileptic Efficacy in Swiss Albino Mice – A Study Protocol
M. M. Nidhin *
Department of Rasa Shastra and Bhaishajya Kalpana,Shri Dhanwantry Ayurvedic College and Hospital, Chandigarh, India.
Bharat Rathi
Department of Ras Shastra and Bhaishajya Kalpana, Mahatma Gandhi Ayurveda College Hospital and Research Centre, Datta Meghe Institute of Higher Education and Research (DU), Sawangi (M) Wardha, India.
Renu Rathi
Department of Kaumarbhritya, Mahatma Gandhi Ayurveda College Hospital and Research Centre, Datta Meghe Institute of Higher Education and Research (DU), Sawangi (M) Wardha, India.
Saranya S. Kumar
Department of Kayachikitsa, Shri Dhanwantry Ayurvedic College and Hospital, Chandigarh, India.
*Author to whom correspondence should be addressed.
Abstract
Background: Epilepsy accounts for a significant proportion of the world’s disease burden, affecting around 50 million people worldwide. With the increased incidence rate of epilepsy, a few treatment modalities as well as formulations are being developed in recent years, but the complete recovery from the symptoms of epilepsy is not recorded till today. However, there is a search for a formulation that shows quick and longstanding efficacy on epilepsy. Saindavadhi Ghrita is one such formulation mentioned in Yogaratnakara Apasmara Chikista.
Aim: A comparative Pharmaceutico-analytical study of Saindavadhi Ghrita prepared with Murchchhit and Amurchchhit Ghrita (MSG & ASG) and evaluation of its antiepileptic efficacy in Swiss albino mice.
Methodology: Preparation of Saindavadhi Ghrita will be carried out with Murchchhit and Amurchchhit Ghrita and an analytical study will be done. Prepared Saindavadhi Ghrita (MSG & ASG) will be evaluated for its antiepileptic action on Swiss albino mice.
Observations & Results: Analysis and Experimental study shall be documented and presented in the form of data, photographs, tables, charts, etc. as applicable. The data obtained will be analyzed by using a one-way analysis of variance (ANOVA) followed by Dunnett’s multiple comparison t-tests as a post hoc test for determining the level of significance of the observed effects.
Conclusion: MSG is expected to be to show significant antiepileptic efficacy in Swiss albino mice as compared to ASG.
Keywords: Sneha kalpana, ghrita murchchhana, Saindavadhi Ghrita, antiepileptic study