Association of Hematological Parameters with Nottingham Histologic Grades of Breast Carcinoma in South Indian Population
U. Sunderesh Kamal Chander *
Department of Pathology, Saveetha Medical College and Hospital, Chennai, India.
M. Vanishree
Department of Pathology, Saveetha Medical College and Hospital, Chennai, India.
Sonti Sulochana
Department of Pathology, Saveetha Medical College and Hospital, Chennai, India.
Marlina Rowland
Department of Pathology, Saveetha Medical College and Hospital, Chennai, India.
*Author to whom correspondence should be addressed.
Abstract
Aim: To determine the most reliable hematological markers for the prognosis of breast cancer. To evaluate the correlation between hematological parameters and histopathological grading.
Study Design: A retrospective study
Place of Study: This study was carried out in Saveetha Medical College and Hospital, Tamil Nadu, India.
Methodology: Study was started after obtaining the approval from the ethics committee. Histopathological grades 1, 2 and 3 of breast cancer patients were correlated with their hematological parameters.
Results: Out of 104 cases of breast carcinoma, maximum of cases were seen in histopathological grade 2, followed by grade 3 and grade 1 respectively. On correlation with hematological parameters, Hb concentration, RBC count, PCV , MCV , TLC , DLC(neutrophil, lymphocytes) and Absolute lymphocyte count was decreased as the grade increase. RDW increased with higher the grade. Neutrophil lymphocytes ratio showed statistically increased increase in histopathological grade 3 when compared to grade 1.
Conclusion: Our study showed that the hematological parameters like hemoglobin, RBC count, PCV, WBC count, platelet count, absolute neutrophil count, absolute lymphocyte count, NLR in breast cancer can be a useful guide for disease progression.
Keywords: Breast carcinoma, histopathological grade, hematological parameters, neutrophil lymphocyte ratio