Effects of Letrozole on Trabecular Diameter of Long Bone: Mouse Model
Muhammad Haroon Khan
Histopathology, Rehman Medical Institute, Peshawar, Pakistan.
Nabila Momin
Anatomy, Kabir Medical College, Peshawar, Pakistan.
Sarah Javed
Histopathology, Rehman Medical Institute, Peshawar, Pakistan.
Faiqa Mobeen
Muhammad Teaching Hospital, Peshawar, Pakistan.
Amna Shah Mehmood
Institute of Pathology and Diagnostic Medicine, Khyber Medical University, Peshawar, Pakistan and Institute of Medical Physics, Martin Luther University, Halle, Germany.
Sana Ullah Khan *
Histopathology, Lady Reading Hospital (Medical Teaching Institution), Peshawar, Pakistan.
*Author to whom correspondence should be addressed.
Abstract
Background: Letrozole, a commonly prescribed Neoadjuvant endocrine therapeutic drug in hormone receptor positive breast cancer females, causes osteoporosis along with several other debilitating effects. The objective of this study was to observe the changes in trabecular diameter of femur of mice after exposure to Letrozole.
Materials and Methods: This Laboratory based experimental study was carried out at Pakistan Council of Scientific and Industrial Research Centre (PCSIR) Peshawar and Khyber Medical University (KMU) Peshawar from 1st of June 2018 till 30th of July 2018. Thirty-three female albino mice were divided into control and experimental groups. The experimental group was given Letrozole drug at a dose of 1mg/kg/day for 28 days. Weight of these thirty-three mice was measured before and after administration of the drug. The animals were then sacrificed. Femurs were dissected and processed to find out changes in its gross morphology, weight, and trabecular diameter.
Results: The overall weight of mice, weight of femur and its trabecular diameter was greater in control Group as compared to experimental Group.
Conclusion: Use of Letrozole can cause significant reduction in trabecular diameter of long bones.
Keywords: Breast cancer, estrogen receptor, Letrozole, osteoporosis