Journal of Pharmaceutical Research International

The use of natural ingredients as a treatment and wound healing has been widely used, one of which is betel leaf (Piper betle Linn). This study aims to analyze and test whether betel leaf extract can accelerate wound healing in male white rats (Rattus norvegicus). This study used an experimental research design. The sample in this study were male white rats grouped randomly into 4 groups with each consisting of 5 rats, then given a 2 cm incision wound and given different treatments. The first group was the treatment groups with 2.5% betel leaf extract cream. The second group was given 5% betel leaf extract cream. Third groups with 10% betel leaf extract cream. The fourth group was the control group with NaCl 0.9%. The length of the wound in each group was observed and measured every day for 14 days. The data obtained is then analyzed using One Way ANOVA. The result showed that the wound healing process between treatment groups differed significantly because the level of effectiveness and optimization of the doses also varied, namely the sequence of treatment groups that accelerated the wound healing process was the betel leaf extract cream 10%, 5%, 2.5% and last NaCl 0.9%. Thus, it was concluded that the giving of betel leaf extract cream can accelerate the healing of wounds in male white rats which are characterized by the higher dosage of betel leaf extract will further accelerate the healing of incisions in male white rats.