Synthesis, Characterisation and Evaluation of Azetidine-2-One Derivative
S. Ramachandran *
Department of Pharmaceutical Chemistry and Analysis, Vels Institute of Science Technology and Advanced Studies (VISTAS), Chennai-600 117, Tamilnadu, India.
S. Dheepika
Department of Pharmaceutical Chemistry and Analysis, Vels Institute of Science Technology and Advanced Studies (VISTAS), Chennai-600 117, Tamilnadu, India.
M. Deepak
Department of Pharmaceutical Chemistry and Analysis, Vels Institute of Science Technology and Advanced Studies (VISTAS), Chennai-600 117, Tamilnadu, India.
M. Duraiseelan
Department of Pharmaceutical Chemistry and Analysis, Vels Institute of Science Technology and Advanced Studies (VISTAS), Chennai-600 117, Tamilnadu, India.
B. S. Chandru
Department of Pharmaceutical Chemistry and Analysis, Vels Institute of Science Technology and Advanced Studies (VISTAS), Chennai-600 117, Tamilnadu, India.
M. Vijey Aanandhi
Department of Pharmaceutical Chemistry and Analysis, Vels Institute of Science Technology and Advanced Studies (VISTAS), Chennai-600 117, Tamilnadu, India.
*Author to whom correspondence should be addressed.
Abstract
Antibacterial, antifungal, anticancer, antitubercular, anti-HIV, analgesic, anti-inflammatory, and ulcerogenic activities have all been documented for azetidinone derivatives.
The reaction of Schiff base((Z)-N (4-dimethylamino)benzylidene)pyrimidine-2-amine) with chloroacetyl chloride yielded a novel chemical called Azetdine-2-one derivative. Fourier Transform Infrared Spectroscopy and Proton Nuclear Magnetic Resonance Spectroscopy were used to confirm the chemical structures of the produced substances. The antimicrobial activity shows that the compound showed mild Antibacterial activity against Staphylococcus aureus and Escherichia coli.
Keywords: Azetidine-2-one derivative, chloroacetyl chloride, Schiff Base