Journal of Pharmaceutical Research International

Drug delivery systems that can sustain therapeutic medication doses that are pharmacologically efficacious for long time spans while also permitting "dosing-on-demand" would be immensely useful in modern medicine. Physicians can choose from a variety of precision delivery options, such as local or systemic circulation, while still ensuring appropriate dose over the duration of treatment with implantable drug delivery systems. These systems have several advantages, including focused local medication delivery at a steady and predetermined pace, which reduces the amount of medication required and the associated negative effects while boosting the efficacy of treatment. These systems are especially useful for conditions including Management of cardiovascular disease, TB, diabetes, cancer, and chronic pain, to mention a few, that require long-term medication or face issues with patient compliance. The first section of this chapter provides an overview of different implantable drug delivery devices, ranging from biomaterial-based to electromechanical. Techniques for optimizing medication delivery are also explored, including approaches to alter drug release patterns and the release kinetics process. After that, prospective therapeutic applications and biocompatibility issues will be briefly discussed. These systems' performance and related applications differ. The performance, functioning principle, fabrication procedures, and dimensional constraints of each technology are highlighted. We look at the current research on implanted drug delivery systems, with an emphasis on application and chip performance, as well as a comparison of passive and active delivery systems. Finally, this article sums up with an overview of implantable drug delivery systems' future prospects, particularly in terms of precision and customised medicine.