Crystallography and Biopharmaceutics of Some Antimalarials
Sunday O. Awofisayo *
Department of Clinical Pharmacy and Biopharmacy, Faculty of Pharmacy, University of Uyo, Nigeria.
Augustine O. Okhamafe
Department of Pharmaceutics and Pharmaceutical Technology, University of Benin, Benin City, Nigeria.
Ehijie F. O. Enato
Department of Clinical Pharmacy and Pharmacy Practice, Faculty of Pharmacy, University of Benin, Benin City, Nigeria.
Matthew I. Arhewoh
Department of Pharmaceutics and Pharmaceutical Technology, University of Benin, Benin City, Nigeria.
*Author to whom correspondence should be addressed.
Abstract
Crystallography is a branch of science that deals with the discerning of the arrangement and bonding of atoms in crystalline solids. Crystal structural differences in the active pharmaceutical ingredient (API)/excipients in multi-source generics of antimalarials may present differences in their physicochemical properties and ultimately the rate and extent of drug absorption. Tackling the menace of the continuing spread of multi-drug resistant Plasmodium falciparum malaria may require the evaluation of the crystal structural influences of orally administered drugs on antimalarial bioavailability.
Keywords: Crystallography, Physicochemical properties, Multi-source, Antimalarial, Biopharmaceutics, Bioavailability