Synthesis, Characterisation and Antimicrobial Evaluations of Acetyloxyphenyl-1,2,3-triazole Linked Hexahydro Acridinediones
P. Shanmugasundaram *
Department of Chemistry, Thiruvalluvar Government Arts College, Rasipuram, Namakkal-637 401,Tamil Nadu, India.
R. Sujatha
Department of Nutrition and Dietetics, N.K.R Government Arts College for Women, Namakkal-637 001, Tamil Nadu, India.
M. Vijey Aanandhi
Department of Pharmaceutical Chemistry and Analysis, School of Pharmaceutical Sciences, Vel's Institute Science, Technology and Advanced Studies (VISTAS), Pallavaram, Chennai-600 117, Tamil Nadu, India.
V. Manivannan
Department of Chemistry, Thiruvalluvar Government Arts College, Rasipuram, Namakkal-637 401,Tamil Nadu, India.
M. Sivaraju
Department of Chemistry, Thiruvalluvar Government Arts College, Rasipuram, Namakkal-637 401,Tamil Nadu, India.
*Author to whom correspondence should be addressed.
Abstract
10-(2-hydroxyphenyl)-hexahydro acridinediones were treated with chloroacetyl choloride to give 10-(2-chloroacetyloxyphenyl) hexahydro acridinediones, which were treated with NaN3 in acetone followed by reaction with DMAD yielded 10-[2-(1-triazolo-4,5-dicarboxymethyl)acetyloxyphenyl]-3,4,6,7,9,10-hexahydro-1,8-(2H,5H)- acridinediones.
Keywords: Antimicrobial, acetyloxyphenyl, acridinediones, triazoles, triazolo-acridinedione