A Review on Anthracycline Induced Cardiotoxicity- A Mechanism-based Approach
Sachin M. Hiradeve
Nagpur College of Pharmacy, Wanadongari, Hingna Road, Nagpur, 441110, Maharashtra, India.
Vaibhav P. Uplanchiwar *
Nagpur College of Pharmacy, Wanadongari, Hingna Road, Nagpur, 441110, Maharashtra, India.
Namrata Mane
Nagpur College of Pharmacy, Wanadongari, Hingna Road, Nagpur, 441110, Maharashtra, India.
Gayatri Katole
Nagpur College of Pharmacy, Wanadongari, Hingna Road, Nagpur, 441110, Maharashtra, India.
Sanjana N. Gaikwad
Nagpur College of Pharmacy, Wanadongari, Hingna Road, Nagpur, 441110, Maharashtra, India.
Mayuri N. Deshmukh
Nagpur College of Pharmacy, Wanadongari, Hingna Road, Nagpur, 441110, Maharashtra, India.
Swati G. Gaikwad
Nagpur College of Pharmacy, Wanadongari, Hingna Road, Nagpur, 441110, Maharashtra, India.
Priya V. Nikam
Nagpur College of Pharmacy, Wanadongari, Hingna Road, Nagpur, 441110, Maharashtra, India.
Abhinav Bais
Nagpur College of Pharmacy, Wanadongari, Hingna Road, Nagpur, 441110, Maharashtra, India.
Vijendra Fulzele
School of Pharmacy, G. H. Raisoni University, G. H. Raisoni Nagar, Saikheda, District Chhindwara, 480106, Madhya Pradesh, India.
Trupti S. Bobade
Reschrone Medico Publisher, Nagpur, Maharashtra, India.
Mohd. Hashim Mansoori
M. S. College of Pharmacy, Kudus Taq. Wada district Palghar, Maharashtra, India.
*Author to whom correspondence should be addressed.
Abstract
Doxorubicin has become one of the most effective chemotherapeutic agents, but its use was complicated by the development of heart failure. Proposed mechanisms for its antitumor effects included intercalation into DNA that caused the prevention of micro molecule synthesis, DNA cross-linkage and binding, DNA damage due to topoisomerase 2b suppression, reactive oxygen species production, and induction of apoptosis. Several drugs such as ACE inhibitors or the angiotensin receptor blockers, beta-blockers and the CHF therapy are used for the treatment processes. The present brief review of the literature, focuses on literature based on the mechanism of anthracycline-induced cardiotoxicity.
Keywords: Cytotoxicity, cardiotoxicity, anthracycline, doxorubicin, daunorubicin