A Novel Synthesis of 1,2,3triazole Substituted Pyrimidine, Pyrazole by Using 1,2,3triazolchalcone
A. J. Shadakshari
Department of Organic Chemistry, Visvesvaraya Technological University Jnana Sangama, Belagavi 590018, University BDT college of Engineering, Davanagere, India.
T. H. Suresha Kumara
Department of Organic Chemistry, Visvesvaraya Technological University Jnana Sangama, Belagavi 590018, University BDT college of Engineering, Davanagere, India.
H. B. V.
Department of Chemistry, School of Chemical Sciences, Kuvempu University, Shankaraghatta-577451, Shivamogga, Karnataka, India.
A. J. Yamuna
Department of Chemistry, School of Chemical Sciences, Kuvempu University, Shankaraghatta-577451, Shivamogga, Karnataka, India.
*Author to whom correspondence should be addressed.
Abstract
A series of 1- benzyl-5-methyl 1,2,3 triazole pyrimidine , 1- benzyl-5-methyl 1,2,3 triazole pyrazole were synthesised by using intermediate as phenyl Substituted prop-2-en-1-one .We obtained pyrazole when we treated propenones by using hydrazine hydrate and we obtained pyrimidine by using urea and thiourea. Conformations of the compounds were done by 1HNMR and C13 NMR analysis and these compounds were screened for antimicrobial activities.
Graphical Abstract
Keywords: Phenyl Substituted prop-2-en-1-one, urea, thiourea, hydrazine hydrate