Phytochemical Investigation and Antidiabetic Activity of Herbal Formulation of Ougeinia oojeinensis Plant Extracts
Dhananjay Rai *
Department of Pharmacy, Mandsaur University, Mandsaur, MP, India.
Vishal Soni
Department of Pharmacy, Mandsaur University, Mandsaur, MP, India.
*Author to whom correspondence should be addressed.
Abstract
The goal of this study was to assess the antidiabetic potential of produced herbal formulations of Ougeinia oojeinensis plant extracts. The results show that phospholipids complex-based drug delivery systems have a lot of promise for increasing the in-vivo antidiabetic activity of plant extracts. The phospholipids complex has a relationship with different physicochemical properties such as size and entrapment effectiveness. In compared to hydroalcoholic extract (200 mg/kg and 400 mg/kg), an improved phospholipids complex formulation can provide a substantial antidiabetic effect at a lower dose (100 mg/kg and 200 mg/kg). At a lower dosage than the hydroalcoholic extract, the extracts improved lipid profile and body weight. As a result, the dosage efficacy ratio was enhanced by using phospholipids complex formulation. The histological alterations of the pancreas and kidney in streptozotocin-nicotinamide caused diabetes were also prevented by an optimised phospholipids complex formulation of Ougeinia oojeinensis extract. As a result, the current investigation found that Ougeinia oojeinensis extract might be beneficial in the treatment of type 1 and type 2 diabetes with aberrant lipid profiles.
Keywords: Ougeinia oojeinensis, antidiabetic, herbal formulation, phospholipids complexes