Assessing the Oral Flora Changes Pre-operatively, Post-operatively and Post Radiotherapy in Patients Having Oral Squamous Cell Carcinoma
Srajan Hora *
Department of Oral and Maxillofacial Surgery, SharadPawar Dental College and Hospital, Datta Meghe Institute of Medical Sciences, Sawangi (Meghe), Wardha(Maharashtra), India.
Prafulla Gaikwad
Department of Oral and Maxillofacial Surgery, SharadPawar Dental College and Hospital, Datta Meghe Institute of Medical Sciences, Sawangi (Meghe), Wardha(Maharashtra), India.
*Author to whom correspondence should be addressed.
Abstract
Background: The occurrence of oral malignancies like oral squamous cell carcinoma has an effect on the microbiota present in the oral cavity. It is observed that radiotherapy exposures can also lead to disturbances within the oral microbiota.
Objectives: To assess the oral microbiota in patients having oral malignancy and in normal healthy individuals, and compare them to evaluate the changes associated with oral malignancies and their treatment.
Methodology: The study will be conducted in the Oral & Maxillofacial Surgery Department at SharadPawar Dental College, DMIMS, Sawangi(Wardha). The study comprises of 50 Participants who will participate in the study after agreeing to an informed consent.
Results: Athorough investigation of the biological behaviour of the microflorawas considered necessary to understand their exact specific roles in the process of carcinogenesis, which can be achieved by isolating the specific associated strains and their consequent profiling using various sequencing methods.
Conclusion: There can be a definite relationship between the prevalence of oral malignancies and their consequent changes in the oral microbiota.
Keywords: Oral squamous cell carcinoma, malignancies, microbiota, pre and post-operativeeffects, radiotherapy