Anti-Inflammatory Effect of Three Novel Hydroxy Flavones
K. Vijay Kumar *
Department of Pharmacology, RKDF Medical College, SRK University, Bhopal, India.
Reena Verma
Department of Pharmacology, RKDF Medical College and Hospital, Bhopal, India.
*Author to whom correspondence should be addressed.
Abstract
Aim: The aim of the present study was to evaluate the anti-inflammatory effect of three 7-hydroxy flavone derivatives; 7-HF, 7,3’,4’-THF, and 7,8,3’-THF,
Materials and Methods: The acute anti-inflammatory effect of 7-hydroxy flavones was the effect of 7-hydroxy flavones on certain mediators of pain and inflammation like cyclooxygenases (COX-1 and COX-2), and pro-inflammatory cytokines (IL-1b and TNF- were investigated by using in vitro tests.
Results: The investigated 7hydroxy flavones produced a significant, the test compounds inhibited both the isoforms of cyclooxygenase, a higher degree of inhibition on COX-2 was evident. Concentration-dependent inhibition of other inflammatory cytokines like tumour necrosis factor-a and interleukin-1b was identified in the present study
Conclusion: conclusion of the present study reveal the pain and anti-inflammatory action of the investigated 7hydroxy flavones. The inhibitory effects of 7hydroxy flavone on various pro-inflammatory cytokines provide evidence for the mechanism of action of these compounds against pain and inflammation.
Keywords: Anti-inflammatory effect, cyclooxygenases, Interleukin-1b, flavone