Structure Based Drug Discovery, Docking, Modelling, Synthesis and Anticancer Screening of Some Novel Quinoline Derivatives
Bharat Shivaji Honde *
Department of Pharmacology, Pravara Institute of Medical Sciences (Deemed University), Loni, 413736, District Ahmednagar, (M.S.), India.
Kunkulol Rahul Rajendra
Department of Pharmacology, Pravara Institute of Medical Sciences (Deemed University), Loni, 413736, District Ahmednagar, (M.S.), India.
*Author to whom correspondence should be addressed.
Abstract
A new series of (2-(substituted-phenyl) quinoline-4-yl) (3-(substituted phenyl)-5-phenyl-1H-pyrazol-1-yl) methanone derivatives was carried out docking modelling and synthesized. Purity was checked by TLC and chemical structures of synthesized compounds were elucidated by their IR, 1HNMR, MS analysis data. The synthesized compounds were screened for anticancer activity by using cell line MCF-7 (Human breast cancer cell line) correlate with docking modelling.
Keywords: IR, MS, 1HNMR, auto dock vina softwere, docking, modelling, quinoline, MCF-7, anticancer