Comparative Evaluation of Salivary Interleukin-18 in Periodontitis Patients with or without Diabetes Mellitus
B. Chithralekha
Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India.
M. Jeevitha *
Department of Periodontics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India.
Selvaraj Jayaraman
Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India.
*Author to whom correspondence should be addressed.
Abstract
Aim: The study was conducted to compare the salivary concentrations of interleukin-18 in periodontitis patients with or without diabetes mellitus
Materials and Methods: The sample size in the study was 30 and categorized into 3 groups, in each group 10 individuals were included in the respective category. The three groups are as follows: Group a- patients with clinically healthy gingiva, Group b- patients with periodontitis and diabetes mellitus, Group c- patients with periodontitis only.
Results: Salivary Interleukin-18 levels were found to be significantly higher (p<0.013) in periodontitis with diabetes mellitus (110±7.0 ng/L) when compared with periodontitis only (70.06±3.5 ng/L) and also when compared with healthy controls (66±5.6 ng/L).
Conclusion: From the study, diabetic patients with periodontitis have increased IL-18 levels than non-diabetic counterparts. Thus salivary IL-18 is an effective non-invasive biomarker associating periodontitis and diabetes mellitus.
Keywords: ELISA, innovative technology, interleukin-18, periodontitis, saliva