Journal of Pharmaceutical Research International

A study on the development of sunscreen gel products from Momordica cochinchinensis(Lour.) Spreng. extract aimed to study phenolic content, inhibitory effect of Elastase and Tyrosinase, product stability, toxicity, astringent effect of M. cochinchinensis extract, skin elasticity value, suitable product formula calculation for preparing sunscreen gel products from M. cochinchinensis extract, and irritation test. The process started fromthe selection of raw materials, preparation of extracts for determining the total phenolic content, development of suitable formula, test of safety and product physical characteristics, and then test of the anti-allergic effect of 10 volunteers to get efficient and safe sunscreen gel from M. cochinchinensis extract. The study result indicated that M. cochinchinensisaril extract had antioxidant activity DPPH of 1.51±0.05 mg/ml, compared to standard substance - Vitamin C, and total phenolic content of 13.18±0.18 (mg equivalent of gallic acid per 100 g - dry weight). Regarding Cytotoxicity at a concentration of 0.0001-1 mg/ml, it revealed that M. cochinchinensisaril extract was not toxic to human skin cells with the cell survival percentage at a concentration of 1 mg/ml equaled to 95.35±1.86 and 88.15±4.73%, respectively. M. cochinchinensisaril extract concentration of 1 mg/ml had astringent effect which can stimulate human skin cells to move together faster than the control group but showed effect slower than Vitamin C concentrate of 1 mg/ml. and did not have inhibitory effect on Elastase and Tyrosinaseenzymes. Regarding M. cochinchinensis seed oil extract, it did not toxic to human skin cells at the concentration of 0.0001-1 mg/ml with the survival percentage equaled to 105.67-111.46%, and had a few antioxidants activity of unsaturated fatty acids with an IPC₅₀ more than 1000 mg/ml. This study was only the development of sunscreen gel products from M. cochinchinensis extract.