Evaluation of Cardioprotective action of Suvarna gairik (Redochre) in Indian Cobra Envenomation, Aluminium Phosphide Poisoning and Doxorubicin Cardiotoxicity in Albino Rats- A Protocol
Santoshi Mane *
Department of Agadtantra, Mahatma Gandhi Ayurved College Hospital and Research Centre, Salod [Hirapur], Datta Meghe Institute of Medical Sciences [Deemed to be University], Wardha, India and Department of Agadtantra, L.R.P. Ayurvedic Medical College, Islampur, Dist-Sangli, Maharashtra, India.
Nilima Wadnerwar
Department of Agadtantra, Mahatma Gandhi Ayurved College Hospital and Research Centre, Salod [Hirapur], Datta Meghe Institute of Medical Sciences [Deemed to be University], Wardha, India.
Sudhir Ninave
Department of Forensic Medicine and Toxicology, Jawaharlal Nehru Medical College, Sawangi (M), Datta Meghe Institute of Medical Sciences [Deemed to be University], Wardha. India.
R. D. Wajgi
Yeshwantrao Chavan College of Engineering, Nagpur, India.
R. R. Dighade
Yeshwantrao Chavan College of Engineering, India.
*Author to whom correspondence should be addressed.
Abstract
Background: Poisoning is major health issue all over the world. Poisoning is one of basic causes for Out Hospital cardiac arrest (OHCA). P-OHCA (Poison induced Out Hospital cardiac arrest) can be prevented by immediate primary management. The agent for poisoning is unknown in most cases, which leads to difficulty deciding the emergency antidote. In Ayurveda Hridyavaranchikitsa (Cardio protection) is one of the treatment modalities mentioned in all types of poisoning as first aid treatment. Suvarna Gairik (Red ochre) is one of drugs mentioned for the cardioprotection. Snake bite and organophosphate poisoning are the threats to life in India. Doxorubicin is commonly used drug for Chemotherapy in malignancies, and its major side effect is cardiotoxicity. Hence these poisonings are included in study.
Aim and Objective: Evaluation of cardioprotective activity of Suvarna Gairik (Red ochre) in cardiac biomarker like Lactate dehydrogenase, Creatinine phosphokinase, Alkaline transferase, Cardiac Troponins and Survival Time in Indian Cobra Envenomation, Aluminium phosphide poisoning and Doxorubicin cardiotoxicity in Albino Rats.
Methodology: Animal study is designed. 56 wistar rats will be divided in 7 groups as Vehicle Control Group, Disease control Group -1 Indian Cobra envenomation, Disease control Group -2Aluminium Phosphide poisoning, Disease control Group -3 Inj. Doxorubicin induced cardiotoxicity, Test Group -1 Indian Cobra Envenomation and Suvarna gairik Test Group -2 Aluminium Phosphide poisoning and Suvarna gairik Test control Group 3- Inj. Doxorubicin cardiotoxicity and Suvarna gairik.
Results: Outcome will be assessed in between groups and among groups.
Conclusion: Suvarna Gairik (Red ochre) may show statistical significant cardioprotective activity.
Keywords: Cardioprotective action, hridyavaranchikitsa, Suvarna gairik (Red ochre), Indian cobra envenomation, aluminium phosphide, doxorubicin cardiotoxicity