To Assess the Level of Vit B12, Vit C and Homocysteine in Chronic Smokers in Central India
Dattu Hawale
Department of Biochemistry, Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences, Sawangi (Meghe), Wardha, India.
Ranjit S. Ambad *
Department of Biochemistry, Datta Meghe Medical College, Shalinitai Meghe Hospital and Research Centre, Nagpur (Datta Meghe Institute of Medical Sciences, Sawangi (Meghe), Wardha), India.
Minal Kalambe
Department of OBGY, Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences, Sawangi (Meghe), Wardha, India.
*Author to whom correspondence should be addressed.
Abstract
Background: Smoking is related to an increased risk of morbidity and mortality. Cigarette smoking has been related to higher levels of homocysteine in the blood. Both have been associated with a higher risk of cardiovascular disease. Smokers also have lower levels of vitamin B12, which affects homocysteine levels by serving as a cofactor or co substrate (folate) for the enzymes that regulate the metabolism of homocysteine.
Materials: This study was a case-control study, conducted in the Department of Biochemistry and medicine at DMMC & SMHRC, Nagpur in collaboration with ABVRH, Sawangi (Meghe). In the present study, the total number of subjects included was 200 having age Group between 30-60. The subjects were divided in two groups. Group 1: 100 subjects chronic smokers and Group 2: 100 subjects non- smokers.
Results: The homocysteine concentration significantly increased in group 1 ( chronic smokers) 18.50±8.40 as compared to group 02( non smokers ) 8.30±5.30 and p value p<0.005.vitamin B12 concentration significantly decreased in group 01 ( chronic smokers) 340.80±124.70 as compared to group 02 (non smokers) 485.45±175.68 and p value p<0.005. vitamin c concentration significantly decreased in group 1 (chronic smokers) 0.46±0.07 as compared to group 02 (non smokers) 1.12±0.15 and p value p<0.005.
Conclusion: On the basis of findings we concluded that the smoking increases Homocysteine levels and lowers the level of Vit B12 and Vit C leading to increase cardiovascular disease risk among chronic smokers.
Keywords: Smoking, Homocysteine, Vit B12, Vit c, CVD