Theophylline Derivatives' In-vivo Analgesic and Anti-Inflammatory Activities
Faruk Alam
Faculty of Pharmaceutical Science, Assam Down Town University, Panikhaiti, Gandhinagar, Guwahati, Assam-781026, India.
Ruhul Amin
*
Faculty of Pharmaceutical Science, Assam Down Town University, Panikhaiti, Gandhinagar, Guwahati, Assam-781026, India.
Biplab Kumar Dey
Faculty of Pharmaceutical Science, Assam Down Town University, Panikhaiti, Gandhinagar, Guwahati, Assam-781026, India.
Josef Yakin
Faculty of Pharmaceutical Science, Assam Down Town University, Panikhaiti, Gandhinagar, Guwahati, Assam-781026, India.
Smriti Rekha Chanda Das
Girijananda Chowdhury Institute of Pharmaceutical Science (GIPS), NH37, Hatkhowapara, Azara, Guwahati, Assam-781017, India.
Mohidul Islam
Faculty of Pharmaceutical Science, Assam Down Town University, Panikhaiti, Gandhinagar, Guwahati, Assam-781026, India.
Himangshu Deka
Faculty of Pharmaceutical Science, Assam Down Town University, Panikhaiti, Gandhinagar, Guwahati, Assam-781026, India.
Republica Borgohain
Faculty of Pharmaceutical Science, Assam Down Town University, Panikhaiti, Gandhinagar, Guwahati, Assam-781026, India.
Durgaprasad Kemisetti
Faculty of Pharmaceutical Science, Assam Down Town University, Panikhaiti, Gandhinagar, Guwahati, Assam-781026, India.
*Author to whom correspondence should be addressed.
Abstract
The reaction of theophylline and chloro-acetyl chloride produced an exceptional series of substituted theophylline derivatives (3A-3D), followed by ammonium thiocyanate and substituted aromatic aldehyde, and these synthesized derivatives were screened to study their analgesic and anti-inflammatory activities. UV, IR, H-1 NMR, mass spectral data, and CHN activities were used to describe the compounds, which were shown to be considerably efficacious at 100 mg/kg p.o., as well as experimental results that were statistically significant at the p <0.01 and p <0.05 levels.
Keywords: Theophylline, analgesic, anti-inflammatory