Role of Surgical Intervention in Hereditary Spherocytosis with Haemolytic Anaemia, Splenomegaly and Jaundice
K. Senthil Kumar
Department of General Surgery, Chettinad Hospital and Research Institute, Kelambakkam, Chengalpattu District, Tamil Nadu-603103, India.
K. Abinaya
Department of General Surgery, Chettinad Hospital and Research Institute, Kelambakkam, Chengalpattu District, Tamil Nadu-603103, India.
R. Anantharamakrishnan
Department of General Surgery, Chettinad Hospital and Research Institute, Kelambakkam, Chengalpattu District, Tamil Nadu-603103, India.
K. Pranay
Department of General Surgery, Chettinad Hospital and Research Institute, Kelambakkam, Chengalpattu District, Tamil Nadu-603103, India.
*Author to whom correspondence should be addressed.
Abstract
haemolytic anaemia, splenomegaly and jaundice, admitted in Chettinad hospital and research institute during one year period from January 2019 to January 2020. Surgical intervention is indicated for selected patients with hereditary spherocytosis with haemolytic anaemia and jaundice to abate the hemolytic process after correction of anaemia with blood transfusion. Pigmented gallstones are seen in more than 50% cases for which incidence increases with severity of hemolysis and with age. Complications include aplastic anemia (most common after parvovirus B19 infection), haemolytic crisis during inter-current infection, megaloblastic crisis – during folic acid deficiency, cardiomyopathy, hematological malignancies.
Keywords: Surgical management, hematological malignancies, hemolysis, spherocytosis