Association of Fibroblast Growth Factor 21 with Lipid Profile, MDA and AOPP in Patients with Type 2 Diabetes Mellitus
P. Divya *
Department of Biochemistry, MES Medical College and Hospital, Perinthalmanna, Kerala, India.
R. Inmozhi Sivakamasundari
Department of Biochemistry, Rajah Muthiah Medical College, Annamalai University, Tamilnadu, India.
T. K. Jithesh
Department of Biochemistry, MES Medical College and Hospital, Perinthalmanna, Kerala, India.
K. Santha
Department of Biochemistry, Rajah Muthiah Medical College, Annamalai University, Tamilnadu, India.
K. Shifa
Department of Biochemistry, MES Medical College and Hospital, Perinthalmanna, Kerala, India.
M. Nakkeeran
Department of Biochemistry, Dhanalakshmi Srinivasan Medical College and Hospital Perambalur, Tamilnadu, India.
*Author to whom correspondence should be addressed.
Abstract
Background: Diabetes mellitus is rising all over the world due to population growth, aging, urbanisation, and the increase of obesity due to physical inactivity, characterized by persistent high blood glucose levels associated with aberrations in lipid, carbohydrate, and protein metabolisms leading to water and electrolyte imbalance. Cardiovascular diseases are the leading causes of mortality in diabetic patients. Mechanisms such as oxidative stress, lipid metabolism imbalance, as well as myocardial cell apoptosis are key factors to facilitate the progression of Diabetic cardiomyopathy.
Aim: The aim of this study was to assess FGF-21 levels and their association with lipid profile parameters and oxidative stress in patients with type 2 diabetes mellitus.
Methods: A patient based cross-sectional study was conducted among the subjects with history of type 2 DM for the past 10 years.
Results: Variations in FBS, T.C, TG, LDL, HDL, VLDL, FGF-21, MDA and AOPP levels among cases and controls were depicted in Table 2. There was an increase in all these parameters in cases compared to controls whereas HDL showed a decrease among cases.
Conclusion: Our study concluded that there is a significant correlation between fibroblast growth factor 21 (FGF-21), oxidative stress, and abnormal lipid profile in type 2 diabetic patients. We would recommend further studies to explore the role of FGF21 as an important marker in predicting cardiovascular risk in diabetic patients.
Keywords: FGF21-Fibroblast growth factor21, Lipid Profile, T2DM-Type 2 Diabetes mellitus, MDA- Malondialdehyde, AOPP- Advanced oxidation protein products