Journal of Pharmaceutical Research International

Background: Punica granatum belongs to the family punicaceae. Pomegranate has a reservoir of secondary metabolites which possess free radical scavenging activity. Pomegranate has high antioxidants content, which helps in the delayed progress of atherosclerosis, cancer and ageing. Gout is a chronic metabolic disease. It is caused due to increased deposition of monosodium urate crystals in joints. It is caused due to increased intake of purine rich food. Xanthine oxidase converts hypoxanthine to uric acid. Xanthine oxidase (XO) plays an important role in the regulation of production of uric acid. Many research has been done in the extract to analyse the pharmacological characteristics and its beneficial uses. Pomegranate is widely consumed and used as preventive and therapeutic agents.

Aim: The aim of this study is to analyse phytochemical constituents, antioxidant and anti gout activity of aqueous seed extract of Punica granatum.

Methods: Aqueous seed extract of Punica granatum was prepared and analysed for its phytochemical, antioxidant and anti gout potential by using statistical methods.

Results: Phytochemicals such as flavonoids, alkaloids, terpenoids, steroids were present in aqueous extract of Punica granatum. IC₅₀ of antioxidant activity of aqueous seed extract of Punica granatum was found to be 280µg/ml. The extract also exhibited anti gout potential with an IC₅₀ = 310 µg/ml. P value is < 0.05 so, it is significant.

Conclusion: Aqueous seed extract of punica granatum can be used to treat gout and to combat various other disorders and also have antioxidant and phytochemical activity. It will be an alternative for synthetic drugs. Herbal extracts are more preferred for its accessibility, cost effectiveness and less side effects. The combined effects of antioxidant and xanthine oxidase inhibitors will be helpful in hyperuricemia treatment.