A Case of Wilson’s Disease Presenting with Persistant Hemolysis
Vrinda Vijayakumari
Department of General Medicine, Chettinad Hospital and Research Institute, Kelambakkam, Chettinad Academy of Research and Education, Tamilnadu, India.
Kaliyannan Mayilananthi
Department of General Medicine, Chettinad Hospital and Research Institute, Kelambakkam, Chettinad Academy of Research and Education, Tamilnadu, India.
Durga Krishnan
Department of General Medicine, Chettinad Hospital and Research Institute, Kelambakkam, Chettinad Academy of Research and Education, Tamilnadu, India.
Ramprasath Anbazhagan
Department of General Medicine, Chettinad Hospital and Research Institute, Kelambakkam, Chettinad Academy of Research and Education, Tamilnadu, India.
Gaurav Narayanan
Department of General Medicine, Chettinad Hospital and Research Institute, Kelambakkam, Chettinad Academy of Research and Education, Tamilnadu, India.
*Author to whom correspondence should be addressed.
Abstract
Wilson’s disease is one the rare autosomal recessive disorders of copper metabolism due to mutation in ATP7B gene located in chromosome 13. The mutations of this gene cause accumulation of copper in different tissues such as brain, liver, and eyes. The clinical presentation usually reflects this tissue distribution and varies from asymptomatic patients to those with hepatic or neuro-psychiatric manifestations. Here, we report an interesting case of Wilson’s disease which presented with mild persistent hemolysis leading to pre hepatic and post hepatic jaundice. He also had hepatocellular jaundice due to liver injury.
Keywords: Wilson’s disease, Coomb’s negative hemolytic anemia, gall stones