Role of Pentraxin-3 in Periodontal Inflammation - A Comprehensive Review
Syed Wali Peeran
Department of Dentistry, Armed Forces Hospital Jizan, Jizan, KSA.
Ahmed Elhassan
Benghazi College of Dentistry, Benghazi University, Benghazi, Libya.
Tazeen Dawood
Department of Preventive Dental Science, College of Dentistry, Jazan University, KSA.
Karthikeyan Ramalingam
*
Department of Oral Pathology, Saveetha Dental College, Chennai, India.
Syed Ali Peeran
College of Dentistry, Jazan University, KSA.
Fatma Ahmed
Faculty of Dentistry, Sebha University, Sebha, Libya.
Abdul-Aziz Ahmed A. Adawi
Armed Forces Hospital Jizan, Jizan, KSA.
*Author to whom correspondence should be addressed.
Abstract
Acute phase reactants like C-reactive protein (CRP), and pentraxin 3 (PTX3) are increased with inflammation and tissue injury. PTX3 is an acute phase protein and a member of the long pentraxin family. CRP is synthesized in the liver but PTX3 is generated locally at the inflammatory site. It is a fluid-phase pattern-recognition molecule that regulates antimicrobial immunity and inflammation by interfering with selectin-dependent neutrophil recruitment and regulating the complement cascade. Hence, PTX3 could be used as a potential biomarker to identify inflammatory response in both acute and chronic diseases. In this review, we discuss the role of PTX3 in periodontal inflammation.
Keywords: Acute phase reactants, pentraxins, PTX3, periodontitis, inflammation