Impact of Alternative Routes and Timing of Dopamine and Mannitol Administrations to Reduce Negative Properties of Extended Cardiopulmonary Bypass on Renal Function in Coronary Artery Operations
Iqra Ejaz
PMC #: 89543-P, Allama Iqbal Memorial Hospital, Sialkot, Pakistan.
Sadaf Arshad
PMDC # :68697-P, Nishtar Hospital, Multan, Pakistan.
Mian Seher Munir
PMC #: 94079-P, DHQ Teaching Hospital, Gujranwala, Pakistan.
Muhammad Usman
PMDC #: 87319-P, Pakistan Institute of Medical Science Hospital Islamabad, Pakistan.
Sohail Zafar
PMDC #: 60525-P, Combined Military Hospital, Quetta, Pakistan.
Faiza Hanif *
PMC #: 59534-P, PGR, Mphill Anatomy, PGMI, Lahore, Pakistan.
*Author to whom correspondence should be addressed.
Abstract
Objectives: To analyze impact of alternative routes and timing of dopamine and mannitol administrations to reduce negative properties of extended cardiopulmonary bypass on renal function in coronary artery operations.
Methods: Set I (n: 26 individual): Mannitol (1 g/kg) has been introduced to the CPB priming solution. Set II (n: 25 patients): Even during interval among anesthetic induction and operation, 3 g/kg/min of IV dopamine was delivered. Group III (n = 25 patients): 2 g/kg/min IV dopamine was provided among anesthesia initiation and operation conclusion, and 1 g/kg mannitol were added to priming solution for CPB. Furosemide was administered to Group IV (n = 26 cases) when urine production was poor.
Results: There would be a substantial rise in the post-operative urine microalbumin/creatinine ratios over all classes (p 0.06), as well as a rise in cystatin-c in Set 1, 2, and 3 (p 0.02).
Conclusions: Researchers suggest that combining dopamine infusion (1 g/kg/min) and mannitol (2 g/kg) throughout CPB seems to be the more actual method for preventing detrimental possessions of CPB on renal functioning.
Keywords: Alternative routes, pharmacological protection, renal function, coronary artery surgery