Cytotoxic Effect of Lingzhi Extracts on Gefitinib-resitant Lung Cancer Cells
Nguyen Hai Dang *
Insitute of Marine Biochemistry, Vietnam Academy of Science and Technology, 18-Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam.
Pham Thanh Binh
Insitute of Marine Biochemistry, Vietnam Academy of Science and Technology, 18-Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam.
Nguyen Thi Tham
Insitute of Marine Biochemistry, Vietnam Academy of Science and Technology, 18-Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam.
Bui Thi Mai Anh
Insitute of Marine Biochemistry, Vietnam Academy of Science and Technology, 18-Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam.
Nguyen Phuong Dai Nguyen
Department of Biology, Faculty of Natural Science and Technology, Tay Nguyen University, 567 Le Duan, Dac Lac City 630000, Vietnam.
Nguyen Tien Dat *
Insitute of Marine Biochemistry, Vietnam Academy of Science and Technology, 18-Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam.
*Author to whom correspondence should be addressed.
Abstract
Aims: The present study was carried out to investigate the cytotoxicity of extracts from Ganoderma and Amauroderma lingzhi species collected in Tay Nguyen, Vietnam.
Methods: Mushroom samples were extracted by methanol and the cytotoxicity was performed by 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyltetrazolium bromide (MTT) method.
Results: Among twelve extracts prepared from Ganoderma and Amauroderma species, six samples significantly inhibited the proliferation of gefitinib-resistant NSCLC cell lines NCI-H1975 and A549. Amauroderma rugosum exhibited cytotoxic effects against both cell lines in comparison with etoposide.
Conclusion: The obtained results suggested that the Tay Nguyen lingzhi could be regarded as a promising candidate for natural sources of epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs).
Keywords: Non-small Cell Lung Cancer (NSCLC), EGFR-TKI, ganoderma, Amauroderma, ganodermataceae.