Journal of Pharmaceutical Research International

Background: The updated guidelines by CDC (center for disease control) narrated the importance of using the dataprovided by hospital antibiogram for initial prescription of managing the infections. Therefore the current study had been planned to formulate the antibiogram in a tertiary care hospital of Islamabad.

Objectives: To identify the local antibiotic susceptibility pattern against various isolates of urine pathogens.

Materials and Methods: A descriptive cross sectional study was conducted at the Pathology department of Al Nafees Medical College & Hospital, Islamabad, Pakistan. The duration of study was 04 months i.e between1^st June to 1^st Oct. 2015. Total 336 suspected urinary tract infection, urine specimens (indoor and outdoor) received for culture and sensitivity were included in the study. Recommended clean catch method was advised for urine sample collection. The specimen processing was done by following the three days recommended protocols for urine cultures by Clinical and laboratory standard institutes (CLSI).Frequencies and percentages were the numerical variables extracted by using the SPSS version 16.

Results: Out of total 336 samples, 9.8% (n=33) urine cultures were positive. Escherichia coli (E. coli) was present in (60.6%), Klebsiella pneumoniae in (12.1%), Pseudomonas aeruginosa in (9.09%), Proteus mirabilis in (6.06%), Morganella morganii in (6.06%) and Staphylococcus saprophyticus in (6.06%). The drugs of choice for E. coli are quinolones and aminoglycosides by showing the sensitivity of about (75%) each. For Klebsiella pneumoniae, the ideal antibiotics are aminoglycosides (85.1%) and 2^nd generation cephalosporins (85%). For Pseudomonas aeruginosa, extended spectrum penicillin, quinolones, 2^nd and 3^rd generation cephalosporins are the most suitable ones showing the sensitivity of (100%) each.

Conclusion: Quinolones, aminoglycosides, 2^nd and 3^rd generation cephalosporins are the drugs of choices for thetreatment of urine infections.