Predictor of Severity of Lung Injury and Oxygen Saturation in COVID- 19 Patients
Fahimeh Shahjooie
Department of Emergency Medicine, Baqiyatallah University of Medical Sciences, Baqiyatallah Hospital, Tehran, Iran.
Sadrollah Mahmudi *
Department of Emergency Medicine, Baqiyatallah University of Medical Sciences, Baqiyatallah Hospital, Tehran, Iran.
Somayeh Mohammadi
Department of Cardiology, Imam Khomeini Hospital complex (IKHC), Tehran University of Medical Sciences, Tehran, Iran.
Hassan Goodarzi
Trauma Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Mehrdad Farajy
Department of Emergency Medicine, Baqiyatallah University of Medical Sciences, Baqiyatallah Hospital, Tehran, Iran.
Mohammadreza Ghanee
Trauma Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Akbar Ghorbani Alvanegh
Human Genetics Research Center, Baqiyatallah Medical Science University, Tehran, Iran.
Amirhossein Ghazale *
Student Research Committee, Baqiyatallah University of Medical Sciences, Tehran, Iran.
*Author to whom correspondence should be addressed.
Abstract
Introduction: Wide spectrum of clinical features of COVID-19 was seen from mild to severe. This is very important to determine the severity of disease, early management of severe disorder may increase the chance of survival.
Methods: This cross sectional study perform on 150 patients with mean age of 53 years that refer to from 21 February to 19 April 2020.
Result: The most comorbidity disease HTN, DM and IHD with prevalence of 26.2%, 20%, 11.3% which had higher severity of lung disease. There was a significant relationship between age, lymphopenia, CRP, IHD, DM, shortness of breath and body pain with the severity of lung injury, shortness of breath had higher severity of lung injury but myalgia had a lower severity rather than the others. level of the LDH was associated with chest CT scan score and so severe disease Further results showed that the mean±SD of LDH in 3 CT group were 576.30±214.82, 641.89± 277.07, 919.92± 382.14 in CT score less than 20, 20-50 and more than 50 respectively (P=0.002).
According this study there was significant relationship between age, BMI, CRP, shortness of breath and fever with blood oxygen saturation. Further results showed that the correlation between LDH and oxygen saturation was r=-0.31 (p=0.002)
Keywords: COVID-19, intensive care unit, Lactate Dehydrogenase, Body Mass Index