Overview on Complex Regional Pain Syndrome: A Review
Hani Mohammed Alabdaly *
Department of Chairman Neurology, Neurorehabilitation and Spinal Cord Injuries, Neurology Residency Training Program, King Saud Medical City/Riyadh-Saudi Arabia and Schwarzwald Klinik Neurology, Germany.
Shahd Ali H. Alramadhan
Royal College of Surgeons, Dublin.
Abdulrahman Jaser F. Almutairi
Majmaah University, Saudi Arabia.
Tariq Hamad H Alotaibi
Shaqra University, Saudi Arabia.
Ahmed Abdulrahman A. Ammar
University of Jeddah, Saudi Arabia.
Hind Khalid Albahli
Qassim university, Saudi Arabia.
Nouf Zayed O. AL-Mutairi
Majmaah University, Saudi Arabia.
Samirah Nawaf Alrashidi
Majmaah University, Saudi Arabia.
Turki Fahad O. Alotaibi
Huraymila general hospital, Saudi Arabia.
Shumukh Fahad Ayesh Alshammari
King Abdulaziz Specialist Hospital, Aljouf, Saudi Arabia.
Abdullah Saad M. Alahmari
Imam Mohammad Ibn Saud Islamic University, Saudi Arabia.
Khaled Ali K. Alkhudhairi
Imam Mohammad Ibn Saud Islamic University, Saudi Arabia.
Daliah Abdulrahman Alharbi
Imam Mohammad Ibn Saud Islamic University, Saudi Arabia.
*Author to whom correspondence should be addressed.
Abstract
Complex regional pain syndrome (CRPS) is a neuropathic pain disease characterized by the presence of allodynia, hyperalgesia, sudomotor and vasomotor abnormalities, and trophic alterations. CRPS can be caused by a variety of degrees or types of tissue damage, but it has also been reported in the absence of injury or after lengthy periods of immobility. A fracture is the most prevalent injury linked to the development of CRPS. CRPS is thought to be caused by a complex process involving both the peripheral and central nerve systems, according to a recent acceptance. Patients with CRPS are said to have all of the symptoms of inflammation, including heat, discomfort, redness, and swelling. CRPS symptoms have been greatly reduced by corticosteroids in several clinical studies. The diagnosis of CRPS is mostly dependent on a patient's medical history and clinical examination, which includes a variety of tests that can help rule out other diseases. Given the syndrome's complexity, it's doubtful that focusing on a single mechanism will be successful. Combination therapy, like with other chronic conditions, may be the future of CRPS treatment. In this review we will be looking at disease definition, pathophysiology, and treatment.
Keywords: Complex regional pain syndrome, neuropathic pain, injury