Angiopoietin-like Protein 3 AND Cardiovascular Disease: A Mini Review
Srinidhi Rai *
Department of Biochemistry, NITTE (Deemed to be University), KS Hegde Medical Academy (KSHEMA), Mangalore-575018, India.
*Author to whom correspondence should be addressed.
Abstract
Objective of the review is to explore the role of angiopoietin like 3 protein (ANGPTL3) as a risk factor for cardiovascular disease. ANGPTL3 (human), one member of the angiopoietin-like protein (ANGPTL) family, has been identified as an important regulator of lipid metabolism. Dyslipidemia, characterized by elevation of plasma low density lipoprotein cholesterol (LDL-C), triglyceride (TG) and reduction of plasma high density lipoprotein cholesterol (HDL-C), has been verified as a causal risk factor for cardiovascular diseases (CVD), leading to a high mortality rate in general population. There may be an association between ANGPTL3, dyslipidemia, diabetes and cardiovascular risk.
Keywords: Angiopoietin -like 3, hyperlipidemia, T2DM, CVD