Assessment Swot on Performance of Micronized Itraconazole against Candida albicans and Aspergillus niger for Superior Health Security
N. V. S. Venugopal *
Department of Chemistry, Institute of science, GITAM (Deemed to be niversity), Visakhapatnam A.P, India.
K. Bujji Reddy
Department of Chemistry, Institute of science, GITAM (Deemed to be niversity), Visakhapatnam A.P, India.
*Author to whom correspondence should be addressed.
Abstract
Background: Antifungal medication is used in adults to indulge infections caused by fungi. This includes infections in any part of the body including the lungs, mouth or throat, toenails, or fingernails. The widespread fungal pathogens causing stern insidious infections surrounded by immuno compromised patients are Candida albicans and Aspergillus niger. Itraconazole, is an antifungal medication used to treat a number of fungal infections. Itraconazole undergoes rapid metabolism to form hydroxyitraconazole, which also contributes to the anti-fungal activity exhibited by the parent compound. In the present study the assessment of plain Itraconazole and micronized Itraconazole material for increasing health safety and its biological evaluation by using Candida albicans and Aspergillus niger was reported.
Methods: The determination of particle size of the micronized material which is a very fine powder and its characteristics was carried out by Dynamic light scattering(DLS) and Scanning Electron Microscopy(SEM).Structural identification was done by UV-spectroscopy and Fourier transform Infrared spectroscopy(FT-IR).
Results: An active pharma ingredient having antifungal activity was selected and micronized using Microniser to reduce the particle size as small as possible. The product antifungal activity was reviewed between untreated material(large particle size, 200 microns) and reduced particle size(micro particles, 2.72 microns). Size reduction showed an increased efficiency of antifungal activity
Conclusion: The antifungal activity of Itraconazole can be enhanced if the coarse large particles are micronized to significantly (>70 folds) smaller particles.
Keywords: Itraconazole, Micronization, Electron microscopy, Bioassay