Recent Developments and Biological Activities of 5-Oxo-Imidazolones Derivatives: A Review
N. Yellasubbaiah
Deptarment of Pharmaceutical Chemistry, SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur, Chengalpattu (District), Tamilnaadu-603203. India.
V. Velmurugan *
Deptarment of Pharmaceutical Chemistry, SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur, Chengalpattu (District), Tamilnaadu-603203. India.
B. Nagasudha
Deptarment of Pharmaceutical Chemistry, CES College of Pharmacy, Chinnatekur, Kurnool (District), Andhra Pradesh – 518218. India.
*Author to whom correspondence should be addressed.
Abstract
Heterocyclic compounds are essential primary units for both the synthetic and natural starting points. 5-oxo-imidazolone is a 5-member ring system that contains 3 carbons and 2 nitrogens that are arranged at 3 and 1 positions, and ─C═O at the 5th position of the ring. 5-oxo-imidazolone is known as a privileged molecule because of its all biological potency. This biological property increased the attention of many investigators to analyze this ring system and expose several activities. The present review aims to outline the various activities reported on the synthesis and the biological potencies of 5-oxo-imidazolone derivatives. 5-oxo-imidazolone is an important pharmacophore in modern drug discovery.
Keywords: 5-oxo-imidazolone, biological activities, pharmacophore