Comparing the Efficacy of 2% Diltiazem Gel with 0.2% Glyceryl Trinitrate in Anal Fissure
Ehsanullah Malik
Department of Surgery, CMC, SMBBMU Larkana, Pakistan.
Sania Bhatti
Department of Surgery, CMC, SMBBMU Larkana, Pakistan.
Qararo Shah
Shaheed Mohtarma Benazir Bhutto Medical University Larkana, Pakistan.
Muharram Ali Abbasi
Department of Surgery, CMC, SMBBMU Larkana, Pakistan.
Khushbakhat Abro
Department of Anatomy, CMC, SMBBMU Larkana, Pakistan.
Vaqar-E-Sahar Shah
Department of Surgery, CMC, SMBBMU Larkana, Pakistan.
Fahad Jibran Siyal
Department of Pharmacology, CMC, SMBBMU Larkana., Pakistan.
Dua Rabel Siyal *
Shaheed Mohtarma Benazir Bhutto Medical University Larkana, Pakistan.
Sumbul Masood
Peoples University of Medical and Health Sciences for Women, Nawabshah, Pakistan.
Abdul Basit Gopang
Department of Pharmacology, CMC, SMBBMU Larkana., Pakistan.
Arsalan Humayun
Department of Community Dentistry, BADC, SMBBMU Larkana, Pakistan.
*Author to whom correspondence should be addressed.
Abstract
Objective: To compare the efficacy of 2% diltiazem gel with 0.2% glyceryl trinitrate in patients presenting with chronic anal fissure at Tertiary Care Hospital, Larkana.
Methodology: This prospective comparative Study was conducted at department of Surgery ward-II Chandka Medical Hospital, Larkana from 14-01-19 to 14-07-19. A total of 130 patients who were treated as OPD cases were included in this study. Each patient detailed history & clinical examination, details of symptomatology was recorded in a epically diagnosed proforma. These patients were randomly divided in two equal groups i-e group A 65 patients and group B 65 patients. Group A patients were treated with 02% glyceryl trinitrate and group B patients were treated with diltiazem gel 02%. All the patients of group A & B were followed up to 02 months after start of leadema as a OPD cases.
Results: A total of 130 patients (65 each in 2% diltiazem gel with 0.2% glyceryl trinitrate group) were included. Mean age in both groups was 42.56±3.91 and 41.71±4.01. 46 (70.8%) and 19 (29.2%) were male and female in Group A and 39 (60%) and 26 (40%) were male and female in Group B. Efficacy of 2% diltiazem gel with 0.2% glyceryl trinitrate in patients presenting with chronic anal fissure was 76.9% and 50.8% respectively.
Conclusion: DTZ (2%) and GTN (0.2%) are equally effective in healing anal fissures. DTZ is better than GTN as it causes less side effects, low recurrence rate, healing rate and therefore better compliance.
Keywords: Efficacy, diltiazem, gel, glyceryl trinitrate and fissure in ano