An Update on Transfusion Related Immunomodulation (TRIM) in a Time of COVID- 19 Pandemic
Emmanuel Ifeanyi Obeagu
*
Department of Medical Laboratory science, Imo State University, Owerri, Nigeria.
Quratulain Babar
Department of Biochemistry, Government College University, Faisalabad, Pakistan.
Immaculata Ogochukwu Uduchi
Department of Medical Laboratory Science, Nnamdi Azikiwe University, Nnewi Cmpus, Nnewi, Anambra State, Nigeria.
Adaobi Maryann Ibekwe
Department of Nursing Science, Nnamdi Azikiwe University, Nnewi Campus, Nnewi, Anambra State, Nigeria.
Udunma Olive Chijioke
Department of Health Administration and Management, Faculty of Health Sciences, University of Nigeria, Enugu Campus, Enugu State, Nigeria.
Chukwuma J. Okafor
Department of Pathology and Biochemistry, State University of Zanzibar, Tanzania.
C. C. N. Vincent
Department of Nursing Science, Imo State University, Owerri, Nigeria.
*Author to whom correspondence should be addressed.
Abstract
Recipients' immune systems are triggered by blood and blood component therapy. Transfusion-related immunomodulation (TRIM) is a complicated immunological response to transfusion that results in immunosuppression. The mechanisms of TRIM include the presence of residual white blood cells and apoptotic cells, the infusion of immunosuppressive cytokines that are present in donor components or that occur during blood processing, the transfer of metabolically active growth factor-loaded particles and extracellular vesicles, and the presence of hemoglobin or extracellular vesicles binds to hemoglobin. TRIM variables include donor-specific factors and processing variables. TRIM can explain, at least partially, the controversial negative clinical results observed in patients with covid19. Many potential treatment methods have been used in clinical practice, including supportive interventions, immunomodulators, antiviral therapy, and infusion of convalescent plasma. Here, we summarize current potential treatments for COVID-19 infection-related diseases and discuss the clinical value of blood transfusion-related technologies for COVID-19 treatment in blood transfusion-related immune regulation.
Keywords: Transfusion related immunomodulation, COVID-19 pandemic, immunity, blood, recipients