Idiopathic Thrombocytopenic Purpura in Post COVID-19 Condition: Case Study
Ch K. V. L. S. N. Anjana Male
Department of Pharmaceutical Chemistry and Phytochemistry, Nirmala College of Pharmacy, Atmakuru, Mangalagiri-522503, A. P, India.
Kommuri Vyduryam *
Department of Pharmacy Practice, Nirmala College of Pharmacy, Atmakuru, Mangalagiri-522503, A. P, India.
N. V. Yaseswi
Department of Pharmacy Practice, Nirmala College of Pharmacy, Atmakuru, Mangalagiri-522503, A. P, India.
V. Pravallika
Department of Pharmacy Practice, Nirmala College of Pharmacy, Atmakuru, Mangalagiri-522503, A. P, India.
A. Javed Akhtar
Department of Pharmacy Practice, Nirmala College of Pharmacy, Atmakuru, Mangalagiri-522503, A. P, India.
R. Piety Christiana
Department of Pharmacy Practice, Nirmala College of Pharmacy, Atmakuru, Mangalagiri-522503, A. P, India.
P. Joy Nissi
Department of Pharmacy Practice, Nirmala College of Pharmacy, Atmakuru, Mangalagiri-522503, A. P, India.
K. Sravya
Department of Pharmacy Practice, Nirmala College of Pharmacy, Atmakuru, Mangalagiri-522503, A. P, India.
*Author to whom correspondence should be addressed.
Abstract
A 50 years old woman was referred to hospital with complaints of bluish black discoloration of skin or multiple ecchymosis since 6 days and skin rashes, pink changes or petechiae changes since 1 week, dark color stools since 3 days. She had a history of COVID-19 positive on past ‘‘3 months’’ back and she received the corticosteroids, antiviral drugs, broad spectrum antibiotics, anticoagulants, and vitamin B and C supplements. Now patient is admitted and investigated for further management. Her bone marrow examination reveals marrow cytological features are compatible with immune thrombocytopenic Purpura and peripheral examination reveals red cells are microcytic hypochromic with elongation forms, platelets are markedly reduced and elevation of CRP, reduction of the Hb, PCV, MCH, MCV, MCHC, APTT, Serum vitamin B12, Lymphocytes and her HRCT-Chest shows CORADS 5, Rapid antigen test shows positive. A review on introduction of the disease, etiology, pathogenesis, pathophysiology, mechanism of thrombocytopenia in COVID-19 patients and grading is explained in literature review.
Keywords: Idiopathic thrombocytopenia, petechiae, ecchymosis, purpura, corona virus disease, antiviral drugs