To Fabricate and Evaluate the Wound Healing Activity of Herbal Medicated Plasters Containing the Extracts Obtained from Tridax procumbens and Azadirachta indica
Nikhil M. Satpute *
Nagpur College of Pharmacy, Wanadongri, Hingna Road, Nagpur-441110, India.
Ravi Kalsait
Nagpur College of Pharmacy, Wanadongri, Hingna Road, Nagpur-441110, India and Datta Meghe Medical College, Shalinitai Meghe Hospital and Research Centre, Nagpur, India and Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences Sawangi (Meghe) Wardha, India.
Abhinav Bais
Nagpur College of Pharmacy, Wanadongri, Hingna Road, Nagpur-441110, India and Datta Meghe Medical College, Shalinitai Meghe Hospital and Research Centre, Nagpur, India and Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences Sawangi (Meghe) Wardha, India.
Narendra Dighade Komal Meshram
Nagpur College of Pharmacy, Wanadongri, Hingna Road, Nagpur-441110, India and Datta Meghe Medical College, Shalinitai Meghe Hospital and Research Centre, Nagpur, India and Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences Sawangi (Meghe) Wardha, India.
Dhruba Hari Chandi
Nagpur College of Pharmacy, Wanadongri, Hingna Road, Nagpur-441110, India and Datta Meghe Medical College, Shalinitai Meghe Hospital and Research Centre, Nagpur, India and Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences Sawangi (Meghe) Wardha, India.
*Author to whom correspondence should be addressed.
Abstract
The present research work is to fabricate medicated plaster containing herbal extracts for wound healing properties. Till date no herbal medicated plaster have been prepared and evaluated using the extracts obtained from the plants Neem and Coat button. The objective of the present study is to provide the herbal medicated plasters to the society. The major advantage of this medicated herbal plaster is its safety, efficacy, portability and efficiency. There is much more study such as Collection of plant, Extraction of plant materials and their antimicrobial test, Evaluation of qualitative and quantitative test, Estimation of total phenolic content, Antioxidant study, Antimicrobial study, Estimation of patch test, Antimicrobial studies of patch test. The plant extracts were quantitatively analysed for total flavonoids content, total phenolic content, and antioxidant activity. Methanolic extract of Azadirechta indica and Tridax procumbens has shown presence of high content of flavonoids and total phenolic content. Also the Azadirachtin content in the neem extracts was determined. All the six extracts AIME, AIPE, AIAE, TPME, TPPE and TPAE were subjected to antimicrobial activity. In patch test FII batch shows the excellent antimicrobial activity.FII patch was selected for fabrication of plasters which was then subjected to the pharmacological study. FII patch possess the maximum wound healing activity by using the methanolic extracts of AIME, TPME and AIPE.
Keywords: Neem, coat button, antimicrobial test, antioxidant study, qualitative and quantitative test, patch test