Prescribing Pattern and Medication Related Problems in Hospitalized Diabetic Patients: A Hospital-Based Study
Journal of Pharmaceutical Research International,
Aim: To assess the drug-related problems (DRPs) and World Health Organization (WHO) core prescribing indicators among hospitalized diabetic patients.
Methodology: A prospective, observational study was made among the diabetic inpatients of the General Medicine Department of a tertiary care hospital located in Tirupati, Andhra Pradesh, India. A suitable data collection form was used to collect the data pertaining to demographics, clinical variables, DRPs, and WHO prescribing indicators. Descriptive statistics like frequency, mean, and percentage were used to represent the demographics, distribution of DRPs, and prescribing indicators in the study. Inferential statistics like Chi-square test was employed to test the significant association between the demographics and occurrence of DRPs.
Results: A total of 199 diabetic patients were enrolled in this study. The mean age of the study participants was 55.8±11.3. The study shows the prevalence of DRPs in diabetic in-patients was 48.7%. The most commonly identified DRPs are drug interactions (53; 45.3%), adverse drug reactions (24; 20.5%), and untreated indication (21; 17.9%). Patient characteristics like, advanced age (≥60 years), presence of co-morbid condition, comprising more than 5 drugs in prescription, and stay in the hospital for more than four days are significantly associated with the development of DRPs. Findings of WHO indicators show the average number of drugs, percentage of drugs prescribed by the generic name, percentage of encounters with an antibiotic, injection, and from essential drug list have deviated from standards of WHO.
Conclusion: The prevalence of DRPs in diabetic in-patients was 48.7%. Drug interactions and adverse drug reactions are the most common DRPs found in our study. Developing the drug policy guidelines focused on factors associated with DRP and WHO prescribing indicators may reduce the burden of DRPs and improves patient outcomes.
- prescribing pattern
- drug use indicators
- drug-related problems.
How to Cite
Animaw W, Seyoum Y. Increasing prevalence of diabetes mellitus in a developing country and its related factors. PLoS One. 2017;12(11):e0187670.
Cho NH, Shaw JE, Karuranga S, Huang Y, Fernandes JD, Ohlrogge AW, et al. IDF diabetes atlas: Global estimates of diabetes prevalence for 2017 and projections for 2045. Diabetes Res Clin Pract. 2018;138:271-81.
Cheema A, Adeloye D, Sidhu S, Sridhar D, Chan KY. Urbanization and prevalence of Type 2 Diabetes in Southern Asia: A systematic analysis. J Glob Health. 2014; 4(1):010404.
Hurst C, Thinkhamrop B, Tran HT. The association between hypertension comorbidity and microvascular complications in type 2 diabetes patients: A nationwide cross-sectional study in Thailand. Diabetes Metab J. 2015;39(5): 395-404.
Gastelurrutia P, Benrimoj SI, Espejo J, Tuneu L, Mangues MA, Bayes-Genis A. Negative clinical outcomes associated with drug-related problems in heart failure (HF) outpatients: Impact of a pharmacist in a multidisciplinary HF clinic. J Card Fail. 2011;17(3):217-23.
Zaman Huri H, Fun Wee H. Drug related problems in type 2 diabetes patients with hypertension: A cross-sectional retrospective study. BMC Endocr Disord. 2013;13(1):2.
Zaman Huri H, Chai Ling L. Drug-related problems in type 2 diabetes mellitus patients with dyslipidemia. BMC Public Health. 2013;13(1):1192.
Kaufmann CP, Stämpfli D, Hersberger KE, Lampert ML. Determination of risk factors for drug-related problems: A multidisciplinary triangulation process. BMJ Open. 2015;5(3):006376.
Goruntla N, Mallela V, Nayakanti D. Impact of one-dose package dispensing with patient counseling on medication adherence in geriatrics suffering from chronic disorders. CHRISMED J Health Res. 2018;5(1):18-22.
Zaman Huri H, Fun Wee H. Drug related problems in type 2 diabetes patients with hypertension: A cross-sectional retrospective study. BMC Endocr Disord. 2013;13:2.
Abdulmalik H, Tadiwos Y, Legese N. Assessment of drug-related problems among type 2 diabetic patients on follow up at Hiwot Fana Specialized University Hospital, Harar, Eastern Ethiopia. BMC Res Notes. 2019;12(1):771.
Hailu Chare Koyra, Seble Bancha Tuka, Efrata Girma Tufa. Epidemiology and predictors of drug therapy problems among type 2 diabetic patients at Wolaita Soddo University Teaching Hospital, Southern Ethiopia. American Journal of Pharmacological Sciences. 2017;5(2): 40-8.
Haugbølle LS, Sørensen EW. Drug-related problems in patients with angina pectoris, type 2 diabetes and asthma – interviewing patients at home. Pharm World Sci. 2006; 28(4):239-47.
Mechessa DF, Kebede B. Drug-related problems and their predictors among patients with diabetes attending the ambulatory clinic of Gebre Tsadik Shawo General Hospital, Southwest Ethiopia. DMSO. 2020;13:3349-57.
May M, Schindler C. Clinically and pharmacologically relevant interactions of antidiabetic drugs. Therapeutic Advances in Endocrinology. 2016;7(2):69-83.
Demoz GT, Berha AB, Alebachew Woldu M, Yifter H, Shibeshi W, Engidawork E. Drug therapy problems, medication adherence and treatment satisfaction among diabetic patients on follow-up care at Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia. Lacetera N, editor. PLoS ONE. 2019;14(10):0222985.
Roozendaal BW, Krass I. Development of an evidence-based checklist for the detection of drug related problems in type 2 diabetes. Pharm World Sci. 2009; 31(5):580-95.
Austin RP. Polypharmacy as a risk factor in the treatment of type 2 diabetes. Diabetes Spectrum. 2006;19(1):13-6.
Abstract View: 0 times
PDF Download: 0 times