Maternal Serum Levels of Alpha Tumour Necrotic Factor, Interleukin 10, Interleukin 6 and Interleukin 4 in Malaria Infected Pregnant Women Based on Their Gestational Age in Southeast, Nigeria

Main Article Content

Obeagu, Emmanuel Ifeanyi
Esimai, Bessie Nonyelum
Ekelozie, Ifeoma Stella
Asogwa Eucharia Ijego
Amaeze Augustine Amaeze
Chukwu, Stella Nchekwubedi
Amaeze, Florence Ngozi
Ugwuja, Mabel Chikodili
Chukwu, Sunday Kyrian

Abstract

Malaria has been reported as a condition caused by infestation with Plasmodium parasite species, is a major public health problem globally especially in developing countries like Nigeria. This study was carried out in Federal Medical Centre Umuahia in Abia State, Nigeria. A study was done to determine the maternal serumlevels of alpha tumour necrotic factor, interleukin 10, interleukin 6and interleukin 4 in malaria infected pregnant women based on their gestational age in Southeast, Nigeria. A total of 150 subjects between the ages of 18-45 years were recruited for the study comprising of fifty (50) subjects each of the 3 trimesters. Commercial ELISA Kit by MELSIN Medical Co Limited was used to measure all the cytokines. The results of Table 1 showed no significant difference of TNF-α (p=0.346), IL-10 (p=0.059), IL-6 (p=0.811) and IL-4 (p=0.257) of malaria infected pregnant women at first trimester and second trimester respectively. The results of Table 2 showed no significant difference of TNF-α (p=0.642), IL-10 (p=0.678), IL-6 (p=0.551) and IL-4 (p=0.280) of malaria infected pregnant women at first trimester and third trimester respectively. The results of Table 2 showed no significant difference of TNF-α (p=0.062), IL-10 (p=0.016), IL-6 (p=0.352) and IL-4 (p=0.914) of malaria infected pregnant women at first trimester and third trimester respectively. The study showed no changes in the cytokines studied among the malaria infected pregnant women based on gestational ages except when IL-10 was compared between the subjects on second trimester and third trimester. This study shows that malaria infection does not changes these cytokines in pregnant women based on gestational ages except the il-10 when compared at second trimester and third trimester but changes when compared at other trimesters.

Keywords:
Alpha tumour necrotic factor, interleukin 10, interleukin 6 and interleukin 4 malaria infected pregnant women, gestational age.

Article Details

How to Cite
Ifeanyi, O. E., Nonyelum, E. B., Stella, E. I., Ijego, A. E., Amaeze, A. A., Nchekwubedi, C. S., Ngozi, A. F., Chikodili, U. M., & Kyrian, C. S. (2020). Maternal Serum Levels of Alpha Tumour Necrotic Factor, Interleukin 10, Interleukin 6 and Interleukin 4 in Malaria Infected Pregnant Women Based on Their Gestational Age in Southeast, Nigeria. Journal of Pharmaceutical Research International, 32(14), 64-70. https://doi.org/10.9734/jpri/2020/v32i1430607
Section
Original Research Article

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