Ameliorative Effect of Nigella sativa Oil against Paracetamol Induced Hepatic and Renal Damages in Rats
Mohammed Nazer Hasan *
Department of Pharmacology, Maulana Azad Medical College, New Delhi, India.
Rahat Ali Khan
Department of Pharmacology, Jawaharlal Nehru Medical College, Aligarh, India.
Mohammed Nasiruddin
Department of Pharmacology, Jawaharlal Nehru Medical College, Aligarh, India.
Aijaz Ahmed Khan
Department of Anatomy, Jawaharlal Nehru Medical College, Aligarh, India.
*Author to whom correspondence should be addressed.
Abstract
mol (750 mg/kg) only and Group III to IV were test groups treated with Paracetamol (750 mg/kg) and Nigella sativa oil (1 & 2 ml/kg respectively) for 7 days. On 8th day all rats were sacrificed and blood were collected for liver and renal function tests and tissue samples for histo-pathological examination.
Results: Paracetamol caused marked hepatic and renal damages which were prevented by Nigella sativa oil in dose dependent manner.
Conclusion: Nigella sativa oil showed significant hepato- and reno-protection against Paracetamol induced damages.
Keywords: Nigella sativa oil, paracetamol, hepatoprotection, nephroprotection