In-Vivo Studies of the Angiogenic Potential of Mandur Bhasma
Ekta Tomar
Department of Rasashastra & Bhaishjya Kalpana, D Y Patil University, School Of Ayurveda, Nerul, Navi Mumbai, India.
Sonali Wairagade *
Department of Kayachikitsa, Datta Meghe Ayurved Medical College Hospital and Research Centre, Wanadongri, Nagpur (MS). , India.
Arachana Gharote
Department of Rasashastra & Bhaishjya Kalpana, D Y Patil University, School Of Ayurveda, Nerul, Navi Mumbai, India.
Ranjit S. Ambad
Department of Biochemistry, Datta Meghe Medical College, Shalinitai Meghe Hospital & Research Centre Wanadongri, Hingana, Nagpur-441110, Maharashtra, India.
Dhruba Hari Chandi
Department of Microbiology Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences Sawangi (Meghe), Wardha, India.
*Author to whom correspondence should be addressed.
Abstract
Background: Mandur Bhasma is a herbo-mineral compound. It is prepared by Putapaka method. It is described as Raktasanjanan. In the current study, Mandur Bhasma was prepared with a standardized method w.s.r to Rasatarangini and an experimental study was done to observe the Angiogenic property of Mandur Bhasma. The current study will analyze angiogenic potential of Mandur Bhasma using chick CAM model. This research is intended to study the possible role of Mandur Bhasma on angiogenesis and establishing properties of Mandur Bhasma as an angiogenic by newer means. The experimental study inside the egg shell will be carried out on a membrane known as “chorioallantoic membrane”.
Objectives:
- To Prepare Mandur Bhasma
- Physicochemical and Analytical study of Mandur Bhasma
- To verify the angiogenic potential of Mandur bhasma using the chicken chorioallantoic membrane (CAM) model.
- To compare Angeogenic potential of Mandur bhasma with standard drug progesterone
Methodology: Relevant classical literature regarding Mandur will be reviewed and the data will be collected. Mandur Shodhan with Gomutra and Mandur Maran with Triphala decoction will be done.
Analytical Study like Organoleptic Test for Rasa, Gandha, Varna, Sparsha, Physicochemical Tests and other analytical test like ICP-AES /ICPMS, XRD structure of Bhasma, EDAX-NANO Particle Size will be done.
Expected Results: Changes will be observed in objective outcomes.
Conclusion: Conclusion will be drawn by suitably analyzing data.
Keywords: Angiogenic potential, Mandur bhasma, chick embryo, CAM model