Primary Gastric Lymphoma (Diffuse Large B Cell Type)
Milind Pandey
Department of Pathology, Datta Meghe Medical College, Nagpur, India.
Sunita Vagha
Department of Pathology, Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences Sawangi, Wardha, India.
Raunak Kotecha
Department of Medicine Datta Meghe Medical College Nagpur, India.
Anchal Manchanda
Department of Medicine Datta Meghe Medical College Nagpur, India.
*Author to whom correspondence should be addressed.
Abstract
The most frequent extra-nodal site of lymphoma is gastric lymphoma. The bulk of such lesions are extra nodal marginal zone B mucosal cell lymphoma correlated with lymphoid tissue (MALT) type or diffuse lymphoma of large B cells. We are reporting a case of diffuse major B-Cellular gastric lymphoma, which at first showed indigestion, abdominal heaviness, nausea and widespread weakness with 3-4 months of weight loss. In the antropyloric region and distal portion of lesser curvature of stomach suggestive of aetiology of cancer, the CT abdomen shows circumferential wall thickening. DLBCL has been confirmed by HPE and IHC. The neoplasm entered serosa and was found to have adherence to the pancreatic capsule in stage IIE of gastric lymphoma. Following the staging, treatment with an R-CHOP regimen (rituximab, cyclophosphamide, oncovin (vincristine), hydroxydaunorubicin, and prednisone) was done.
Keywords: Gastric lymphoma, R-CHOP regimen, NHL