Synthesis, Insilico and Antibacterial Activity Studies of Substituted Dihydro-1, 2-Oxazole Benzopyran-2-One Hybrids
Alphonsus D’souza
Department of Chemistry, St. Philomena’s College (Autonomous) Mysuru-560001, Karnataka, India.
Pankaj Kumar *
Department of Pharmaceutical Chemistry, Nitte (Deemed to be University), NGSM Institute of Pharmaceutical Sciences, Deralakatte, Mangaluru-575018, India.
Abhishek Kumar
Department of Pharmaceutical Chemistry, Nitte (Deemed to be University), NGSM Institute of Pharmaceutical Sciences, Deralakatte, Mangaluru-575018, India.
Soundarya M. Rai
Department of Pharmaceutical Chemistry, Nitte (Deemed to be University), NGSM Institute of Pharmaceutical Sciences, Deralakatte, Mangaluru-575018, India.
Prashant Nayak
Department of Pharmaceutics, Nitte (Deemed to be University), NGSM Institute of Pharmaceutical Sciences, Deralakatte, Mangaluru-575018, India.
*Author to whom correspondence should be addressed.
Abstract
A series of substituted dihydro-1, 2-oxazole benzopyran-2-one (SR1-SR6) were synthesized through the intermediate substituted benzopyran-2-one chalcones and were characterized using spectral analysis. Compounds were docked with receptor DNA Gyrase B (PDB code: 5L3J) to know its interaction and binding energy; ranges -3.38 to -2.15 kcal/mol. Further these compounds were tested for antibacterial activity using tube dilution method and MIC values were observed; ranges 3.12 to 25 µg/ml. Compound 3-(5-(m-tolyl)-4,5-dihydroisoxazol-3-yl)-2H-chromen-2-one (SR3) showed the best interaction with binding energy -3.38 kcal/mol and antimicrobial activity having MIC 3.12 µg/ml.
GRAPHICAL ABSTRACT
Keywords: Benzopyran-2-one, chalcones, DNA Gyrase B, antibacterial activity