Recent Advances in Elastic Liposomes: Current Status and Future Perspective
Ravika Nanda
Department of Pharmaceutics, Khalsa College of Pharmacy, Amritsar, India.
Raman Deep Singh Narang
Department of Oral and Maxillofacial Pathology, Sri Guru Ram Das Institute of Dental Sciences and Research, Amritsar, Punjab, India.
Anmoldeep Kaur
Department of Pharmaceutics, Khalsa College of Pharmacy, Amritsar, India.
. Mehak
Department of Pharmaceutics, Khalsa College of Pharmacy, Amritsar, India.
. Karanbir
Department of Pharmaceutics, Khalsa College of Pharmacy, Amritsar, India.
Jasjeet Kaur Narang *
Department of Pharmaceutics, Khalsa College of Pharmacy, Amritsar, India.
*Author to whom correspondence should be addressed.
Abstract
Elastic liposomse (ELs) are the flexible liposomes formulated using phospholipids as well as edge activators. Edge activators provide elasticity to the Els. Els provide advantages over other formulations and have the ability to be delivered by different routes such as topical, transdermal, nasal, ocular, etc. Potential of encapsulating not only lipophillic but also hydrophillic drugs in a single vesicle, ability to pass through channels 1/10th of their diameter, increase in drug permeation, enhanced solubility of drug, patient compliance, prevention of degradation of drug makes them efficient carriers of drugs and leads to increased interest of researchers in them. This review provides understanding of composition of Els, advantages, method of preparation and the adaptable role played by ELs in the administration of numerous drugs for different diseases.
Keywords: Els, advantages, composition, drug delivery