A Comprehensive Mini Review on Co-Crystallization Process
Ananga Mohan Das
Faculty of Pharmaceutical Science, Assam Down Town University, Guwahati, Assam-781026, India.
Ruhul Amin
*
Faculty of Pharmaceutical Science, Assam Down Town University, Guwahati, Assam-781026, India.
Satyabrat Sarma
Faculty of Pharmaceutical Science, Assam Down Town University, Guwahati, Assam-781026, India.
Biplab Kumar Dey
Faculty of Pharmaceutical Science, Assam Down Town University, Guwahati, Assam-781026, India.
Faruk Alam
Faculty of Pharmaceutical Science, Assam Down Town University, Guwahati, Assam-781026, India.
*Author to whom correspondence should be addressed.
Abstract
Co‑crystal chemistry has recently attracted supramolecular scientists. Co-crystals are comprising of hydrogen bonding assembly between different molecules. Many issues related to the performance characteristics of an active pharmaceutical ingredient (API) can be resolved using the co-crystallization approach. A proper understanding of the crystal structure of an API is required for the successful formation of co-crystals with the selected co‑former. Co-crystal chemistry has recently attracted scientists from the super molecules. Co crystals consist of the assembly of hydrogen bonds between various molecules. Many problems related to the performance characteristics of an active pharmaceutical ingredient (API) can be solved using the method of co-crystallization. Co-Crystals offer an alternate pathway where any API, paying little mind to be acidic, essential, or ionizable gatherings, might be co-gem. This aspect also helps to complement existing methods by reintroducing molecules with limited pharmaceutical profiles based on their non-ionizable functional groups.
Keywords: Co-crystals, supramolecular complexes, nonionizable, functional groups, properties, production & characterization, application of co-crystals