Effect of Katakakhadiradi Kashayam on Lipid Profile and Pancreatic Damage in Type II Diabetes Mellitus
Angelie Jessica Subbiah
Department of Research, Bharath Institute of Higher Education and Research, Chennai-600073, Tamil Nadu, India and Department of Anatomy, KSR Institute of Dental Science and Research, Tiruchengodu -637215 Tamil Nadu, India.
M. Kavimani *
Department of Anatomy, Sree Balaji Medical College, Chromepet, Chennai-600044, Tamil Nadu, India.
Mukilan Ramadoss
Department of Physiology, KSR Institute of Dental Science and Research, Tiruchengodu -637215 Tamil Nadu, India.
Mudiganti Ram Krishna Rao
Department of Industrial Biotechnology, Bharath University, Chennai -620073, Tamil Nadu, India.
K. Prabhu
Department of Anatomy, Sree Balaji Medical College, Chromepet, Chennai-600044, Tamil Nadu, India.
*Author to whom correspondence should be addressed.
Abstract
The lipid pattern and levels in diabetic patient are the same as those for subjects with cardiovascular disease. The tactic underlying the oral hypoglycemic agent is to adjust the lipid profile; which can be achieved by herbal therapy. The use of herbs and formulations for attenuation of hyperglycemia and to aid protection against the pancreatic damage is clinically very important. This study was intended to find the efficacy of Katakakhadiradi Kashayam(KKK)on lipid profile and pancreatic tissue damage in streptozotocin-nicotinamide (SN) induced diabetic rats. The diabetic rats were treated with Katakakhadiradi Kashyam orally at doses of 100, 200 and 300 mg/kg/bw. For 28 days and compared with the standard drug Glibenclamide. After the kashayam treatment triglyceride, HDL-cholesterol and total cholesterol level were assayed and pancreatic tissue damage caused by streptozotocin was analysed by histology study.Katakakhadiradi kashayam could restore the serum lipid profile by controlling the blood glucose level and reduce the pancreatic injury in diabetic rats. Supplementation of Katakakhadiradi kashayam showed a significant improvement in the serum lipid profile thus helping in retarding the secondary complications.
Keywords: Diabetes, hyperlipidemia, katakakhadiradi kashayam, pancreas