Screening of Common Potential Inhibitors against Periodontitis and Alzheimer's Disease
Mahvish Khan
Department of Biology, College of Science, Hail University, Hail, KSA.
Saif Khan *
Department of Basic Dental and Medical Sciences, College of Dentistry, Hail University, Hail, KSA.
Mohtashim Lohani
Department of Emergency Medical Services, Faculty of Applied Medical Sciences, Jazan University, Jazan-45142, KSA.
Hazza A. Alhobeira
Department of Restorative Dentistry, College of Dentistry, University of Ha’il, Ha’il-2440, Saudi Arabia.
Shadab Mirza
Department of Clinical Administration, College of Dentistry, Hail University, Saudi Arabia.
Shafiul Haque
Research and Scientific Studies Unit, College of Nursing & Allied Health Sciences, Jazan University, Jazan-45142, Saudi Arabia.
*Author to whom correspondence should be addressed.
Abstract
Introduction: As the amyloid precursor protein performs a remarkable part in chronic periodontitis and the progression of Alzheimer's disease growth, discoveryof novelactive inhibitors of this protein can be of great standing in the treatment of periodontitis. Chronic periodontitis is one of the causative factors and metabolic stressor for diabetes control. In chronic periodontitis and Alzheimer's disease, some molecules have been proposed to inhibit proteins in past.
Methods: This study was planned to find present potent inhibitors,A library of KDM compounds was obtained from Chem Div Database. Here, all complexes with goodglide score were short listed for analysis of protein-ligand interaction. Calculations were carried out to estimate the interaction of the ligands selected in complex with the beta amyloid protein.
Results: Five top hits were found considering Curcuminas reference. Five small molecules have been proposed as possible inhibitors of this protein. Here in this study, we have focused on small molecule lead inhibitors for identification of Chronic Periodontitis and Alzheimer's disease.
Keywords: Chronic periodontitis (CP), Alzheimer’s diseases (AD), docking, virtual screening, beta-secretase protein (amyloid-beta)